EXPRESSIONS OF TIGHT JUNCTION PROTEINS OCCLUDIN AND CLAUDIN-1 ARE UNDER THE CIRCADIAN CONTROL IN THE MOUSE LARGE INTESTINE: IMPLICATIONS IN INTESTINAL PERMEABILITY AND SUSCEPTIBILITY TO COLITIS.

BACKGROUND & AIMS: The circadian clock drives daily rhythms in behavior and physiology.A recent study suggests that intestinal permeability is also under control of the circadian clock.However, the precise mechanisms remain largely unknown.Because intestinal permeability depends on tight junction (TJ) that regulates the epithelial paracellular path

Leishmaniasis is a pestilent affliction that importunately needs better therapeutics necessitated by absence of effective vaccine, emergence as HIV co-infection and the dread of debilitating chemotherapy.The Leishmania parasites incapacitate host macrophages by preventing the formation of phagolysosomes, impeding antigen presentation to T cells, le

Synthesis, characterization, and properties of new thermally curable polysulfone containing benzoxazine moieties in the side chain were investigated.First, chloromethylation and subsequent azidation processes were performed to form polysulfone containing pendant clickable azide groups.Independently, antagonist 3,4-dihydro-3-(prop-2-ynyl)-2H-benzoxa

The heat shock response (HSR) is the main pathway used by cells to counteract proteotoxicity.The inability of differentiated neurons to induce an HSR has been documented in primary neuronal cultures and has been proposed to play a critical role in ageing and neurodegeneration.However, this accepted dogma has not been demonstrated in vivo.We used BA